Patients with rheumatoid arthritis and lupus erythematosus often suffer from a progressive loss of function of kidneys . You begin to understand the relationship between the two diseases.
Patients suffering from systemic autoimmune diseases - such as' rheumatoid arthritis and lupus erythematosus - Often suffer from a progressive loss of renal function. Very little is known about the mechanisms that link the two diseases.
A group of Japanese researchers has begun to shed light on the problem by publishing an article on research about the latest issue of the journal Arthritis & Rheumatism .
Based on their studies show that a critical role in the development of autoimmune glomerulonephritis have platelets.
Based on their studies show that a critical role in the development of autoimmune glomerulonephritis have platelets.
studying a strain of mutant mice, which tend to develop autoimmune diseases, have isolated a subtype of the fact that they suffered in a limited way of glomerulonephritis autoimmmuni resulting from other diseases: a closer examination revealed that while most common in the mutant strain accumulated a high number of platelets in the glomeruli, this did not happen in the subtype in question, which - although having a greater propensity to bleeding - survived twice as long compared to the first.
Further studies have revealed in particular the involvement of Cno protein, which belongs to the family of complex 1 for the biogenesis of lysosome-related organelles (BLOC-1) The findings suggest a link between the mutation - the loss of protein Cno - defects in platelet function and regression of the formations in the renal glomeruli.
This finding suggests the existence of a link between loss of expression of Cno protein, defects in platelet function and regression of the growth of platelet formation in the kidney glomruli. Furthermore, linking these relationships to BLOC-1, which controls lysosomes.
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