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SYNDROME RESEARCH

Multiple sclerosis: a study Verona the role of lymphocytes

A project funded by the European Commission aims to discover the mechanisms that drive the migration of lymphocytes in neurological diseases related to inflammation. The results will be useful to develop new "weapons" not only against multiple sclerosis, but also against epilepsy and Alzheimer's.

Dec. 16 - A new trend in research on neurological diseases is being opened in Verona, at the Department of Diagnostic Pathology and University of Verona. Party these days because "Neutraffiking," a four-year project funded with 1.2 million euro by the European Commission through the bottom of the European Research Council for basic research. The study will seek to understand the role of immune cells in neurological diseases and to identify new potential drug targets in inflammatory diseases of the central nervous system. to coordinate, Gabriela Constantin, associate professor at their university Scala. will MS will investigate the model on which the researchers: the disease is in fact the prototype of autoimmune disease that has an underlying chronic inflammatory process of the central nervous system. In particular, the migration of lymphocytes is a central event in the pathogenesis of multiple sclerosis and its blockade is a very powerful therapeutic approach in this disease and other autoimmune diseases. In recent years it has been demonstrated that the migration of leukocytes in the brain occurs not only in multiple sclerosis but also in other neurological diseases such as epilepsy and Alzheimer's disease. "The main purpose of the project" Neurotrafficking "is the study of the mechanisms that control leukocyte trafficking in neurological diseases in which inflammation is a crucial pathogenetic process," said Constantin. "We will study the interactions between blood leukocytes and endothelial cells lining the inner surface of blood vessels nervous system. " By using advanced techniques of intravital microscopy will identify new molecular mechanisms that control leukocyte migration through the wall of the cerebral vessels. "The leukocyte traffic will then be studied within the nervous system using two-photon confocal microscopy, a technique recently developed by the pioneering group coordinated by Gabriela Constantin," added the Director of the Department of Pathology and Diagnostic Aldo Scarpa. "They will then studied the dynamic interactions between white blood cells and neural cells and will identify new mechanisms involved in the damage induced by leukocytes the nervous system and potential new therapeutic approaches in neurological diseases, "said Scarpa.