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New Diagnostics in Crohn's disease

a monitoring tool for advanced Crohn's disease

PROJECT VIGOR + + OFFER A QUANTITATIVE METHODS FOR ASSESSING THE EXAMS WITH MAGNETIC RESONANCE IMAGING, TO BE USED AS AN ALTERNATIVE TO Colonoscopy

Share A team of researchers funded by the EU will develop a multiscale model to measure the gastrointestinal (GI) that will help doctors to better detect Crohn's disease and provide a precise index of disease severity. Supported with funding of almost € 3 million under the theme "Information and Communication Technologies (ICT) of the Seventh Framework Programme (FP7), its project VIGOR + + (" Virtual gastrointestinal tract ") brings together seven partners from Germany, the Netherlands, Switzerland and the United Kingdom. Over 1 million people in Europe suffer from inflammatory bowel disease (IBD), a term that encompasses a group of diseases in which the intestine becomes inflamed, say the partners VIGOR + +. The Crohn's disease, which affects about 700,000 Europeans, it is one of these diseases. Determine the type of care that a person who has been diagnosed with Crohn's disease needs is essential. The majority of patients undergoing colonoscopy in combination with an analysis of biopsy specimens. But experts believe that this method is invasive, requiring a good job of preparation and the results may be inconclusive. This generates a lot of anxiety in patients. Led by the Delft University of Technology (TU Delft) in the Netherlands, partners VIGOR + + believe their innovative approach will in the future conduct of a smaller number of colonoscopies. A colonoscopy is performed with a hose fitted with a miniature camera that is passed into the rectum, causing much discomfort to patients. The doctors start using laxatives to clear the large intestine of the patient. partners in the project VIGOR + + state that doctors use as an alternative to magnetic resonance tomography (RMT) to monitor the course of the disease and to determine how he is responding to treatment. VIGOR + + will provide the medical world an objective quantitative method to evaluate these tests RMT. This is a win-win situation for both doctors and patients, with analysis more accurate and less discomfort. "The assessment exam is not currently RMT very objective, "explains Professor Jaap Stoker of the Academic Medical Center (AMC), University of Amsterdam, one of the partners VIGOR + +." RMT objective evaluation techniques will allow us to use the RMT to better monitor disease activity in Crohn Crohn's. This could, among other things, have a positive impact on side effects and costs resulting from the prolonged use of drugs to treat the disease. " Usually, an increase or a decrease in disease affects people suffering from Crohn's disease. It is important to regularly assess the stage of the disease to ensure an effective cure. "We will examine methods for objective quantitatively determine the severity of the disease using RMT tests, "said Dr. Frans Vos of the TU Delft and the AMC, which is heading the project." RMT The images make it possible to measure the thickness of the intestinal wall and the degree of vasculature, in addition to the recognition of the various layers of the intestine. These are all indicators of how active Crohn's disease. The only thing required is the intravenous administration of contrast medium. " He goes on to say that VIGOR + + is basically an ICT project." After all, the basis is the recognition of statistical models, "explains Dr. Vos . For that purpose, one of the first things we must do is to analyze large quantities of images RMT. " Source: Cordis (10/02/2011)